Brilliant brothers Langley and Homer Collyer are born into bourgeois New York comfort in settled times, their home a fin-de-siècle mansion on upper Fifth Avenue, their future rosy. But before he is out of his teens Homer begins to lose his sight, Langley returns from the War in Europe with his lungs seared by gas, and when the death of their parents in the influenza epidemic of 1918 leaves the brothers orphaned, they seem perilously ill-equipped to deal with the new era.

E. L. Doctorow's novels include Andrew's Brain, Homer and Langley, The March, City of God, Welcome to Hard Times, The Book of Daniel, Ragtime, Loon Lake, Lives of the Poets, World's Fair, Billy Bathgate and The Waterworks. Among his honours are the National Book Award, two National Book Critics Circle awards, the PEN/Faulkner Award, the Edith Wharton Citation for Fiction, the William Dean Howells Medal of the American Academy of Arts and Letters and the presidentially conferred National Humanities Medal. He died in July 2015.