Este libro es una obra de ficción que describe los eventos de la Gran Plaga de Londres de 1665. La novela se centra en las prácticas y las creencias de aquellos que experimentaron la plaga, y en cómo la ciudad de Londres reacciona a la enfermedad. Defoe utiliza testimonios y documentos históricos para crear un relato realista de los efectos de la epidemia.

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