This updated edition is a comprehensive treatise that spans the complete range of basic biochemistry of bone and cartilage components to the clinical evaluation of disease markers in bone and joint disorders. With contributions from over 75 international experts, Dynamics of Bone and Cartilage Metabolism, Second Edition, is indispensable reading for those involved in skeletal research as well as for rheumatologists, endocrinologists, clinical biochemists, and other clinical disciplines participating in the management of patients with bone and cartilage diseases.

• Part I provides an up-to-date account of current knowledge of the structure, biosynthesis and molecular biology of the major tissue components
• Part II covers the organizational structure and cellular metabolism of bone and cartilage
• Part III deals with the utility of components specific to bone and cartilage as biomarkers of health and disease

PART I Components of the Organic Extracellular Matrix of Bone and Cartilage 1. Structure, Biosynthesis and Gene Regulation of Collagens in Cartilage and Bone 2. Fibrillogenesis and Maturation of Collagens 3. Vitamin K Dependent Proteins of Bone and Cartilage 4. Non-collagenous Proteins; Glycoproteins and Related Proteins 5. Proteoglycans and Glycosaminoglycans 6. Growth Factors 7. Prostaglandins and Proinflammatory Cytokines 8. Integrins and Other Adhesion Molecules 9. Alkaline Phosphatases 10. Acid Phosphatases 11. Matrix Proteinases
PART II Structure and Metabolism of the Extracellular Matrix of Bone and Cartilage 12. Mineralization, Structure and Function of Bone 13. Bone Structure and Strength 14. The Cells of Bone 15. Signalling in bone 16. Parathyroid Hormone: Structure, Function and Dynamic Actions 17. Interaction of Parathyroid Hormone-Related Peptide with the Skeleton 18. The Vitamin D Hormone and Its Nuclear Receptor: Mechanisms Involved in Bone Biology 19. Sex Steroid Effects on Bone Metabolism 20. Physiology of Calcium and Phosphate Homeostasis 21. The Central Control of Bone Remodelling 22. New Concepts in Bone Remodeling 23. Products of Bone Collagen Metabolism 24. Supramolecular Structure of Cartilage Matrix 25. Products of Cartilage Metabolism 26. Fluid Dynamics of the Joint Space and Trafficking of Matrix Products 27. Transgenic Models of Bone Disease
PART III Markers of Bone and Cartilage Metabolism 28. The Role of Genetic Variation in Osteoporosis 29. Measurement of Calcium, Phosphate and Magnesium 30. Measurement of Parathyroid Hormone 31. New Horizons for Assessment of Vitamin D Status in Man 32. Measurement of Biochemical Markers of Bone Formation 33. Measurement of Biochemical Markers of Bone Resorption 34. Variability in the measurement of biochemical markers of bone turnover 35. Validation of Biochemical Markers of Bone Turnover 36. Genetic Markers of Joint Disease 37. Body Fluid Markers of Cartilage Metabolism 38. Laboratory Assessment of Postmenopausal Osteoporosis 39. Monitoring of Anabolic Treatment 40. Monitoring of anti-resorptive treatment 41. Age-Related Osteoporosis and Skeletal Markers of Bone Turnover 42. Osteoporosis in Men 43. Steroid-Induced Osteoporosis 44. Transplantation Osteoporosis: Biochemical Correlates of Pathogenesis and Treatment 45. Secondary Osteoporosis 46. Osteomalacia and Rickets 47. Assessment of Bone and Joint Diseases: Renal Osteodystrophy 48. Primary Hyperparathyroidism 49. Paget's Disease of Bone 50. Metastatic Bone Disease 51. Rare Bone Diseases 52. Osteogenesis Imperfecta 53. Rheumatoid Arthritis and Other Inflammatory Joint Pathologies 54. Osteoarthritis and Degenerative Spine Pathologies