First published in 1997, Principles of Tissue Engineering is the widely recognized definitive resource in the field. The third edition provides a much needed update of the rapid progress that has been achieved in the field, combining the prerequisites for a general understanding of tissue growth and development, the tools and theoretical information needed to design tissues and organs, as well as a presentation by the world's experts of what is currently known about each specific organ system.
This edition includes greatly expanded focus on stem cells, including adult and embryonic stem cells and progenitor populations that may soon lead to new tissue engineering therapies for heart disease, diabetes, and a wide variety of other diseases that afflict humanity. This up-to-date coverage of stem cell biology and other emerging technologies is complemented by a series of new chapters on recent clinical experience in applying tissue engineering. The result is a comprehensive textbook that we believe will be useful to students and experts alike.
New to this edition:
*Includes new chapters on biomaterial-protein interactions, nanocomposite and three-dimensional scaffolds, skin substitutes, spinal cord, vision enhancement, and heart valves
*Expanded coverage of adult and embryonic stem cells of the cardiovascular, hematopoietic, musculoskeletal, nervous, and other organ systems

INTRODUCTION TO TISSUE ENGINEERING1. The History and Scope of Tissue EngineeringJoseph P. Vacanti and Charles A. Vacanti 2. The Challenge of Imitating NatureRobert M. Nerem 3. Moving into the Clinic Alan J. Russell and Timothy Bertram4. Future PerspectivesMark E. Furth and Anthony AtalaPART ONE: THE BASIS OF GROWTH AND DIFFERENTIATION5. Molecular Biology of the CellJonathan Slack 6. Organization of Cells into Higher-Ordered Structures Jon D. Ahlstrom and Carol A. Erickson7. Dynamics of Cell-ECM InteractionsM. Petreaca and Manuela Martins-Green8. Matrix Molecules and Their LigandsBjorn Reino Olsen 9. Morphogenesis and Tissue EngineeringA.H. Reddi 10. Gene Expression, Cell Determination and DifferentiationWilliam Nikovits, Jr. and Frank E. StockdalePART TWO: IN VITRO CONTROL OF TISSUE DEVELOPMENT 11. Engineering Functional TissuesLisa E. Freed and Farshid Guilak 12. Principles of Tissue Culture and Bioreactor DesignR.I. Freshney, B. Obradovic, W. Grayson, C. Cannizzaro and Gordana Vunjak-Novakovic13. Regulation of Cell Behavior by Extracellular ProteinsAmy Bradshaw and E. Helene Sage14. Growth Factors Thomas F. Deuel and Yunchao Chang15. Mechanochemical Control of Cell Fate SwitchingDonald E. Ingber PART THREE: IN VIVO SYNTHESIS OF TISSUES AND ORGANS16. In Vivo Synthesis of Tissues and OrgansBrendan A. Harley and Ioannis V. YannasPART FOUR: MODELS FOR TISSUE ENGINEERING17. Models as Precursors for Prosthetic DevicesEugene Bell 18. Quantitative AspectsAlan J. Grodzinsky, Roger D. Kamm, and Douglas A. LauffenburgerPART FIVE: BIOMATERIALS IN TISSUE ENGINEERING19. Micro-Scale Patterning of Cells and Their Environment Xingyu Jiang, Shuichi Takayama, Robert G. Chapman, Ravi S. Kane and George M. Whitesides20. Cell Interactions with PolymersW. Mark Saltzman and Themis R. Kyriakides21. Matrix EffectsJeffrey A. Hubbell 22. Polymer Scaffold Fabrication Matthew B. Murphy and Antonios G. Mikos23. Biodegradable Polymers James M. Pachence, Michael P. Bohrer and Joachim Kohn24. Micro- and Nanofabricated ScaffoldsChristopher J. Bettinger, Jeffrey T. Borenstein and Robert Langer 25. Three-Dimensional ScaffoldsYing Luo, George Engelmayr, Debra T. Auguste, Lino da Silva Ferreira, Jeffrey M. Karp, Rajiv Saigal and Robert LangerPART SIX: TRANSPLANTATION OF ENGINEERED CELLS AND TISSUES26. Tissue Engineering and Transplantation in the FetusDario O. Fauza 27. Immunomodulation Denise L. Faustman 28. ImmunoisolationBeth A. Zielinski and Michael J. Lysaght 29. Engineering Challenges in Immunobarrier Device DevelopmentAmy S. Lewis and Clark K. ColtonPART SEVEN: STEM CELLS 30. Embryonic Stem CellsAlan Trounson31. Adult Epithelial Tissue Stem CellsChristopher S. Potten and James W. Wilson 32. Embryonic Stem Cells as a Cell Source for Tissue EngineeringAli Khademhosseini, Jeffrey M. Karp, Sharon Gerecht, Lino Ferreira, Gordana Vunjak-Novakovic and Robert Langer33. Postnatal Stem CellsPamela Gehron Robey and Paulo Bianco PART EIGHT: GENE THERAPY34. Gene TherapyRonald G. Crystal and Stefan Worgall35. Gene Delivery into Cells and TissuesAles Prokop and Jeffrey M. Davidson PART NINE: BREAST36. Breast ReconstructionLamont Cathey, Kuen Yong Lee, Walter D. Holder, David J. Mooney and Craig R. HalberstadtPART TEN: CARDIOVASCULAR SYSTEM37. Progenitor Cells and Cardiac HomeostasisAnnarosa Leri, Toru Hosoda, Marcello Rota, Claudia Bearzi, Konrad Urbanek, Roberto Bolli, Jan Kejstura and Piero Anversa38. Cardiac-Tissue EngineeringM. Radisic, H. Park and G. Vunjak-Novakovic 39. Blood Vessels Luke Brewster, Eric M. Brey and Howard P. Greisler40. Heart Valves Peter Marc Fong, Jason Park and Christopher Kane BreuerPART ELEVEN: ENDOCRINOLOGY AND METABOLISM41. Generation of Islets from Stem CellsBernat Soria, Abdelkrim Hmadcha, Francisco J. Bedoya and Juan R. Tejedo42. Bioartificial Pancreas Athanassios Sambanis 43. Engineering Pancreatic Beta-Cells Hee-Sook Jun and Ji-Won Yoon 44.