Principles of Bone Biology provides the most comprehensive, authoritative reference on the study of bone biology and related diseases. It is the essential resource for anyone involved in the study of bone biology. Bone research in recent years has generated enormous attention, mainly because of the broad public health implications of osteoporosis and related bone disorders.

• Provides a "one-stop" shop. There is no need to search through many research journals or books to glean the information one wants...it is all in one source written by the experts in the field
• The essential resource for anyone involved in the study of bones and bone diseases
• Takes the reader from the basic elements of fundamental research to the most sophisticated concepts in therapeutics
• Readers can easily search and locate information quickly as it will be online with this new edition

Part I Basic PrinciplesA. Cell Biology1: Structure, Modeling and Remodeling of Bone / The Size and Shape of Bone as a Site of Metabolic Bone Activity2: Biomechanics of Bone3: Embryonic Development of Bone and the Molecular Regulation of Intramembranous and Endochondral Bone Formation4: Mesenchymal Stem Cells & Osteoblast Lineage5: Transcriptional Control of Osteoblast Differentiation and Function6: Wnt Signaling and Bone7: Sclerostin and Bone8: The Osteocyte9: Cells of Bone: Osteoplast Generation10: Osteoclast Function: Biology and Mechanisms11: RANK Signaling12: Regulating Bone Resorption13: Apoptosis in Bone Cells14: Skeletal Gene Expression in Nuclear MicroenvironmentsB. Biochemistry15: Type I Collagen: Structure, Synthesis, and Regulation16: Collagen Crosslinking & Metabolism17: Bone Matrix Proteoglycans & Glycoproteins18: Osteopontin19: Bone Proteinases20: Integrins and Other Cell Surface Attachment Molecules of Bone Cells21: Intercellular Junctions and Cell-Cell Communication in the Skeletal SystemC. Bone Remodeling and Mineral Homeostasis22: Histomorphometric Analysis of Bone Remodeling23: Phosphorus Homeostasis & Related Disorders24: Magnesium Homeostasis25: Metals in Bone: Aluminum, Boron, Cadmium, Chromium, Lead, Silicon, & Stro26: Biology of the Extracellular Ca2+-Sensing Receptor D. The Hormones of Bone27: Receptors for Parathyroid Hormone (PTH) and PTH-Related Protein28: Parathyroid Hormone - Molecular Biology29: Parathyroid Hormone-Receptor Interactions30: Actions of Parathyroid Hormone on the Vasculature and Cardiovascular System31: The Vascular and Cardiovascular Actions of PTH32: PTH and PTHrP Actions on Kidney and Bone33: Physiological Actions of Parathyroid Hormone and PTH-Related Protein34: Vascular, Cardiovascular and Neurological Actions of Parathyroid-Related Protein35: Vitamin D Nuclear Receptor (VDR) and Plasma Vitamin D-Binding Protein (DBP) Structures and Ligand Shape Preferences for Genomic and Rapid Biological Responses36: Vitamin D Gene Regulation37: Photobiology and Non-Calcemic Actions of Vitamin D38: Calcitonin Structure and Molecular Biology of the Calcitonin Receptor / Calcitonin Gene Family and Receptors: Structure, Molecular Biology, and Effects39: Amylin and Calcitonin Gene-Related PeptideE. Other Systemic Hormones That Influence Bone Metabolism40: Estrogens & Progestins41: The Pharmacology of Selective Estrogen Receptor Modulators42: Mechanisms of Estrogen Action in Bone43: Thyroid Hormone & Bone44: Clinical and Basic Aspects of Glucocorticoid Action in Bone45: Effects of Diabetetes & Insulin on Bone Physiology46: Androgens:Receptor Expression and Steroid Action in Bone47: Kinins & Neuro-Osteogenic Factors48: Regulation of Bone Remodeling by Central and Peripheral Nervous SignalsPatricia DucyF.