Molecular Pathology: The Molecular Basis of Human Disease provides a current and comprehensive view of the molecular basis and mechanisms of human disease. Combining accepted principles with broader theoretical concepts and with contributions from a group of experts, the book looks into disease processes in the context of traditional pathology and their implications for translational molecular medicine. It also discusses concepts in molecular biology and genetics, recent scientific and technological advances in modern pathology, the concept of ""molecular pathogenesis"" of disease, and how disease evolves from normal cells and tissues due to perturbations in molecular pathways.

The book describes the integration of molecular and cellular pathogenesis using a bioinformatics approach and a systems biology approach to disease pathogenesis. It also discusses current and future strategies in molecular diagnosis of human disease, and the impact of molecular diagnosis on treatment decisions and the practice of personalized medicine.

This book is a valuable resource for students, biomedical researchers, practicing physician-scientists who undertake disease-related basic science and translational research, and pathology residents and other postdoctoral fellows.

• Exam Master® web site will host "Self-assessment" questions that students can use to study for the molecular section of the board exam
• Teaches from the perspective of "integrative systems biology,¿ which encompasses the intersection of all molecular aspects of biology, as applied to understanding human disease
• Outlines the principles and practice of molecular pathology
• Explains the practice of "molecular medicine¿ and the translational aspects of molecular pathology

PART I: Essential Pathology - Mechanisms of Disease Molecular Mechanisms of Cell Death Acute and Chronic Inflammation Infection and Host Response Neoplasia PART II: Concepts in Molecular Biology and Genetics Basic Concepts in Human Molecular Genetics The Human Genome: Implications for the Understanding of Human Disease The Human Transcriptome: Implications for the Understanding of Human Disease The Human Epigenome: Implications for the Understanding of Human Disease The Human Proteome: Implications for the Understanding of Human Disease Integrative Systems Biology: Implications for the Understanding of Human Disease PART III:Principles and Practice of Molecular Pathology Pathology: The Clinical Description of Human Disease Molecular Pathogenesis: The Biological Basis of Human Disease Integration of Molecular and Cellular Pathogenesis PART IV: Molecular Pathology of Human Disease Molecular Basis of Cardiovascular Disease Molecular Basis of Hemostatic and Thrombotic Diseases Molecular Basis of Lymphoid and Myeloid Diseases Molecular Basis of Diseases of Immunity Molecular Basis of Pulmonary Disease Molecular Basis of Diseases of the Gastrointestinal Tract Molecular Basis of Liver Disease Molecular Basis of Diseases of the Exocrine Pancreas Molecular Basis of Diseases of the Endocrine System Molecular Basis of Gynecologic Diseases Molecular Basis of Prostate Disease Molecular Basis of Breast Disease Molecular Basis of Skin Disease Molecular Basis of Diseases of the Nervous System PART V: Practice of Molecular Medicine Molecular Diagnosis of Human Disease Molecular Assessment of Human Disease in the Clinical Laboratory Pharmacogenomics and Personalized Medicine in the Treatment of Human Disease