Translating Regenerative Medicine to the Clinic reviews the current methodological tools and experimental approaches used by leading translational researchers, discussing the uses of regenerative medicine for different disease treatment areas, including cardiovascular disease, muscle regeneration, and regeneration of the bone and skin.

Pedagogically, the book concentrates on the latest knowledge, laboratory techniques, and experimental approaches used by translational research leaders in this field. It promotes cross-disciplinary communication between the sub-specialties of medicine, but remains unified in theme by emphasizing recent innovations, critical barriers to progress, the new tools that are being used to overcome them, and specific areas of research that require additional study to advance the field as a whole.

Volumes in the series include Translating Gene Therapy to the Clinic, Translating Regenerative Medicine to the Clinic, Translating MicroRNAs to the Clinic, Translating Biomarkers to the Clinic, and Translating Epigenetics to the Clinic.

• Encompasses the latest innovations and tools being used to develop regenerative medicine in the lab and clinic
• Covers the latest knowledge, laboratory techniques, and experimental approaches used by translational research leaders in this field
• Contains extensive pedagogical updates aiming to improve the education of translational researchers in this field
• Provides a transdisciplinary approach that supports cross-fertilization between different sub-specialties of medicine

Introduction: Regenerative Medicine for Cardiovascular Disease-A Good Start PART I: STEM CELLS:  Chapter 1: Introduction and Overview of Stem CellsChapter 2: Mechanistic Insights from Pathologic Perspective Chapter 3: Large Animal Models to Study Stem Cell TherapySection I. Body's Native Repair MechanismsChapter 4. Evolution of understanding of the mechanisms of repair     Chapter 5: Impact of Age on Stem Cell FunctionSection II: Autologous Bone MarrowChapter 6: Bone Marrow Mononuclear CellsChapter 7: Chronic Limb IschemiaChapter 8: Chronic/Refractory AnginaChapter 9: Acute Myocardial InfarctionA. European Experience:  Andreas ZeiherB. US Experience: Jay Traverse Chapter 10: Chronic Ischemic Heart FailureSection III:  Autologous Adipose Derived Regenerative CellsChapter 11: Adipose TissueSection IV: Allogeneic Alternatives to Autologous Bone MarrowChapter 12: Overview of MSCs     Chapter 13: Allogeneic vs Autologous Source: Comparative EffectsChapter 14: Use of MSCs for AMIChapter 15: Combined Cell StrategiesChapter 16: Heart FailureSection V: Cardiac Progenitor CellsChapter 17:  C-Kit+ cellsChapter 18:  CardiospheresSection VI: Other Allogeneic Sources of Stem CellsChapter 19:  Umbilical Cord, Placenta, EndometriumSection VII. Genetic Engineering/Cell TransformationChapter 20:  Genetic Engineering of Fibroblasts to CardiomyocytesChapter 21:  Transformation to inducible Pleuripotent Stem CellsChapter 22:  Transformation to MAPC'sSection VIII: METHODS OF DELIVERY:  Chapter 23.  Transcoronary and EndocardialChapter 24.  Retrograde and EpicardialPart II. TISSUE ENGINEERING:Chapter 25.  Epicardial PatchChapter 26.  Matrix ScaffoldsChapter 27.  Matrix plus cellsChapter 28.  BiomaterialChapter 29:  OrganogenesisPart III. GENE THERAPY: Chapter 30:  Pre-clinical Identification of target genesChapter 31:  SERCA-2a gene for recovery of inotropic functionChapter 32:  SDF-1 Gene for Heart Failure Non-Inotropic MechanismsChapter 33:  Gene Therapy for Angiogenesis: Chronic Limb Ischemia Chapter 34:  Stem Cells Target Gene Transfected Stem CellsPart IV: FUTURE DIRECTIONS:Chapter 35:  CCTRN: Past, Present, and Vision for the FutureChapter 36:  Signature of Responders-lessons from Bio-RepositoryChapter 37:  Adjunctive therapy with LVADs for RecoveryChapter 38:  Trials in Non-Ischemic Heart Failure  Chapter 39:  Enhancing Stem Cell Homing for Tissue RepairChapter 40:  Stroke: Pre-Clinical and Clinical Trial DataSUMMARY