Neuroinflammation, Second Edition, discusses the role inflammation plays in neuro-inflammatory diseases. As research in neuroinflammation has dramatically increased in recent years, this new edition covers all of the new developments and findings since the first publication nearly a decade ago. Comprehensive coverage of topics includes chapters on multiple sclerosis, optic neuritis and Susac syndrome. New chapters cover the latest research in Epilepsy and Neuroinflammation, Pediatric MS, Pediatric Lupus and Traumatic Brain Injury, amongst other topics.

Inflammation is a central mechanism in many neurological diseases, including stroke, multiple sclerosis, brain trauma and meningitis, and it contributes to the generation of pain. Researchers are now beginning to understand the impact of the immune system on different nervous system functions and diseases, ranging from damage, through tolerance, and to modulation and repair.

• Comprehensively reviews the latest developments in neuroinflammation and neuro-inflammatory diseases
• Written for researchers and clinical practitioners in clinical neuroscience, neurology and immunology
• Includes new chapters on Epilepsy and Neuroinflammation, Pediatric MS, Pediatric Lupus and Traumatic Brain Injury

1. Multiple Sclerosis: clinical Features, Pathophysiology, Diagnosis, and Management 2. Neuttralizing Antibodies and Multiple Sclerosis inthe Era of Disease Modifying Treatments 3. Animal Models of Multiple Sclerosis 4. Neuroimaging of Multiple Sclerosis and Other Immune-Mediated Diseases of Central Nervous System: An Update 5. Role of IL-12/IL-23 in the Pathogenesis of Multiple Sclerosis 6. Acute Transverse Myelitis: Clinical Features, Pathophysiology, and Treatment Options 7. Remyelination in Multiple Sclerosis: A Mechanistic Look 8. The Way Forward With Vitamin D in Multiple Sclerosis 9. Autoimmune Encephalitis: Clinical Features, Pathophysiology, and Management 10. Immune Dysregulation in Epilepsy 11. Neurosarcoidosis: Clinical Features, Pathophysiology, and Management 12. Existing and Emerging Therapies for Multiple Sclerosis 13. Tumefactive Demyelination in Multiple Sclerosis: Clinical Presentation, Pathophysiology and Treatment Options 14. Pediatric Multiple Sclerosis 15. Acute Disseminated Encephalomyelitis: Clinical Presentation, Pathophysiology, Diagnosis, and Treatment 16. Neuromyelitis Optica Spectrum Disorders 17. Optic Neuritis: Clinical Manifestations, Pathophysiology, and Management 18. Ischemic Demyelination 19. Inflammatory Mechanisms in Ischemic Cerebrovascular Disease 20. Two-Pore Domain Potassium Channels (K2Ps) as Drug Targets in Neuroinflammation 21. Interferon Gamma Versus Beta-Interferon in Pathogenesis of Multiple Sclerosis: Battle of Two Interferons 22. Inflammatory Mediators in Obstructive Sleep Apnea 23. Central Nervous System Vasculitis 24. Role of Inflammatory Mechanisms in Guillain-Barre' Syndrome 25. Roles of Macrophages and Astrocytes in Pathogenesis of Multiple Sclerosis 26. Blood-Brain Barrier Disruption During Neuroinflammation 27. Roles of Toll-Like Receptors in Pathophysiology of Alzheimer's Disease and Multiple Sclerosis 28. Role of Neuroinflammation in the Pathophysiology of Traumatic Brain Injury 29. The Contribution of Extra Cranial Venous Drainage to Neuro-Inflammation in Multiple Sclerosis 30. Lymphatic Drainage of the CNS and Its Role in Neuroinflammation and Neurodegenerative Disease 31. A Complete Review on Epigenetic Biomarkers in MS