Principles of Human Organs-on-Chips covers all aspects of microfluidic organ-on-a-chip systems, from fabrication to application and commercialization. Organ-on-a-chip models are created to mimic the structural, microenvironmental and physiological functions of human organs, providing the potential to bypass some cell and animal testing methods. This is a useful platform with widespread applications, frequently in drug screening and pathological studies.

This book offers a comprehensive and authoritative reference on microfluidic organs-on-chips, spanning all key aspects from fabrication methods, cell culture systems and cell-based analysis, to dedicated chapters on specific tissue types and their associated organ-on-a-chip models, as well as their use as disease models, drug screening platforms and more.

Principles of Human Organs-on-Chips helps materials scientists and biomedical engineers to better understand the specific requirements and challenges in the design and fabrication of organ-on-a-chip devices. This book also bridges the knowledge gap between medical device design and subsequent clinical applications, allowing medical professionals to easily learn about related engineering concepts and techniques.

• Describes various microfluidic systems and fabrication methods
• Covers models and applications for a broad range of tissue types, including liver, eye, immune, gut, and more
• Offers an interdisciplinary approach, combining engineering techniques and clinical applications of organs-on-chips

1. Techniques and Materials for the Fabrication of Microfluidic Chips2. Critical Factors Affecting Cells Behaviour in Microfluidic Chips3. Cell-Based Assays on Microfluidic Chips4. Cell Culture Techniques in Microfluidic Chips5. Skin-On-A-Chip6. Blood Vessels-On-A-Chip7. Heart-On-A-Chip8. Liver-On-A-Chip9. Lung-On-A-Chip10. Gut-On-A-Chip11. Kidney-On-A-Chip12. Immune Organs-On-Chip13. Nervous Systems on a Chip14. Eye-On-A-Chip15. Endocrine Organs-On-A-Chip16. Musculoskeletal Tissue-On-a-Chip17. Tumour-On-A-Chip18. Multi Organs-On-A-Chip and Personalized Medicine19. Computational modelling of organ-on-a-chip devices20. Commercialized Microfabricated Cell Chips21. Organs-On-A-Chip: Future perspectives