Advances in Molecular Pathology is an annual review publication that covers the current practices and latest developments in the field of Molecular Pathology. Each issue is divided into sections for comprehensive coverage of all subspecialty areas within molecular pathology, including, Genetics, Hematopathology, Infectious Disease, Pharmacogenomics, Informatics, Solid Tumors, and special topics on COVID-19. The Editor-in-Chief of the publication is Dr. Gregory Tsongalis, a leading expert in the field. Topics covered this year include but are not limited to: Phenotype Association and Variant Pathogenicity Prediction Tools in Genomic Analysis; The application of noninvasive prenatal screening to detect copy number variations; Next generation cytogenomics using optical mapping; Review of molecular in APL; NGS for MRD in acute leukemia; Review of emerging technologies as they pertain to infectious disease testing; Germline genetic variants that predict drug response; Nutrigenomics; PGx of hypertension; Genomic data for blood typing, specifically both through NGS and arrays; Preanalytic Variables and Tissue Stewardship for Reliable Next-Generation Sequencing (NGS) Clinical Analysis; and Cell-free nucleic acids in cancer: Current approaches, challenges, and future directions.

Current Tools, Databases, and Resources for Phenotype and Variant Analysis of Clinical Exome SequencingApplications of Noninvasive Prenatal Testing for Subchromosomal Copy Number Variations Using Cell-Free DNAApplications of Optical Genome Mapping in Next-Generation Cytogenetics and GenomicsDiagnosis of Variant Translocations in Acute Promyelocytic LeukemiaNext-Generation Sequencing for Measurable Residual Disease Assessment in Acute LeukemiaMolecular Profile of BCR-ABL1 Negative Myeloproliferative Neoplasms and Its Impact on Prognosis and ManagementEngineering Consideration for Emerging Essential Nucleic Acid Tests for Point-of>Care DiagnosticsThe Importance of Use of Genetics to Guide Hypertension Therapy: Using b>Blockade as an ExampleEmerging Molecular Diagnostic Methods for Prosthetic Joint InfectionsThe Role of the Human Gutome on Chronic Disease: A Review of the Microbiome and NutrigenomicsBlood Group GenotypingArtificial Intelligence in Anatomic PathologyCell-free Nucleic Acids in Cancer: Current Approaches, Challenges, and Future DirectionsTumor Mutational Burden Calculation and Microsatellite Instability Detection in Clinical Next-Generation Sequencing AssaysOperationalizing Genomic Medicine: Laboratory Practice Considerations Beyond the AssayA PENNdemic Year in ReviewReview of SARS-CoV-2 Antigen and Antibody Testing in Diagnosis and Community SurveillanceThe Genomic Landscape of Severe Acute Respiratory Syndrome Coronavirus 2: Surveillance of Variants of Concern