Multiscale Cell-Biomaterials Interplay in Musculoskeletal Tissue Engineering and Regenerative Medicine addresses the key concepts involved in the interactions between cells and biomaterials in the musculoskeletal tissue engineering and regenerative medicine field. The updated developments and challenges of the mechanisms/mechanobiology and structure-function properties of those interactions, as well as emerging technologies underlying tissue-engineered scaffolding, are carefully discussed. Lastly, cell engineering and cell-based therapies, growth factors/drugs properties, vascularization, immunomodulation are also outlined.

Given the large number of musculoskeletal disorders and related injuries that can affect muscles, bones and joints and lead to severe complications of the neuromuscular system, it is imperative to develop new treatment strategies to delay or repair associated diseases and to promote optimal long-term health.

Section 1: Fundamentals of cell-biomaterials interactions 1. Introduction 2. Fundamentals and mechanisms 3. Cellular signaling processes 4. Cell-protein interactions 5. The microenvironment: Recreate the ECM 6. Surface modifications - topography, porosity 7. Chemotaxis: Soluble morphogens and Growth factors 8. Cell-biomaterials: Vascularization 9. Cell-biomaterials in Immunomodulation 10. Mechanobiology regulation 11. Electrical/Magnetic stimulation

Section 2: Multiscale design, structure/function and processing technologies 12. Introduction 13. Design of polymeric biomaterials at multiscale 14. Design of Calcium phosphates cements: Structure/function 15. Biomimetic micro-/nano- scales design 16. Cells-biomaterials structure-function at different length scales 17. Computational modelling involved in multiscale design 18. Hydrogel systems design: Structure/function 19. Scaffolding design and structure/function: Electrospinning 20. Scaffolding design and structure/function: Advanced manufacturing 21. Scaffolding design and structure/function: Bioprinting 22. Dynamic models for investigating structure/function of biomaterials: Bioreactors 23. Dynamic models for investigating cell-biomaterials interactions: Microfluidics 24. Complex in vitro models for studying cell-biomaterials interactions 25. In vivo animal models 26. Regulatory and clinical translation