In this issue of Neurologic Clinics, guest editor Dr. Carrie M. Hersh brings her considerable expertise to the topic of Multiple Sclerosis. Top experts in the field discuss diagnosis and pathophysiology concepts, treatment, special populations in MS, and contemporary issues related to MS.

• Contains 16 relevant, practice-oriented topics including recent advances in diagnostic, prognostic, and disease monitoring biomarkers in MS; the growing problem of MS misdiagnosis; highly effective therapy versus escalation approaches in early MS; clinical considerations in the diagnosis, management, and treatment of MS in Black and Latinx populations; women's health and pregnancy in MS; the era of COVID-19 in MS care; and more.
• Provides in-depth clinical reviews on multiple sclerosis, offering actionable insights for clinical practice.
• Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

Multiple Sclerosis Diagnostic Delay and Misdiagnosis
Recent Advances in Diagnostic, Prognostic, and Disease-Monitoring Biomarkers in Multiple Sclerosis
Pathophysiology, Diagnosis, Treatment and Emerging Neurotherapeutic Targets for Progressive Multiple Sclerosis: The Age of PIRA
Relationship Between Multiple Sclerosis, Gut Dysbiosis, and Inflammation: Considerations for Treatment
Updates in NMOSD and MOGAD Diagnosis and Treatment: A Tale of Two Central Nervous System Autoimmune Inflammatory Disorders
Advances in Multiple Sclerosis Neurotherapeutics, Neuroprotection, and Risk Mitigation Strategies
Role of B Cells in Relapsing-Remitting and Progressive Multiple Sclerosis and Long-Term Effects of B Cell Depletion
Bruton's Tyrosine Kinase Inhibitors for Multiple Sclerosis Treatment: A New Frontier
Autologous Hematopoietic Stem Cell Transplantation to Treat Multiple Sclerosis
Highly Effective Therapy Versus Escalation Approaches in Early Multiple Sclerosis: What Is the Future of Multiple Sclerosis Treatment?
Leveraging Real-World Evidence and Observational Studies in Treating Multiple Sclerosis
Health, Wellness, and the Effect of Comorbidities on the Multiple Sclerosis Disease Course: Tackling the Modifiable
Clinical and Treatment Considerations for the Pediatric and Aging Patients with Multiple Sclerosis
Women's Health and Pregnancy in Multiple Sclerosis
Multiple Sclerosis in Black and Hispanic Populations: Serving the Underserved
Era of COVID-19 in Multiple Sclerosis Care