The influence of dose grid resolution on beam selection strategies in radiotherapy treatment design.- Decomposition of matrices and static multileaf collimators: a survey.- Neuro-dynamic programming for fractionated radiotherapy planning.- Randomized algorithms for mixed matching and covering in hypergraphs in 3D seed reconstruction in brachytherapy.- Global optimization and spatial synchronization changes prior to epileptic seizures.- Optimization-based predictive models in medicine and biology.- Optimal reconstruction kernels in medical imaging.- Optimal control in high intensity focused ultrasound surgery.

This volume presents a wide range of medical applications that can utilize mathematical computing. This work grew out of a workshop on optimization which was held during the 2005 CIM Thematic Term on Optimization in Coimbra, Portugal. It provides an overview of the state-of-the-art in optimization in medicine and will serve as an excellent reference for researchers in the medical computing community and for those working in applied mathematics and optimization.