This book combines the latest clinical developments in the treatment of patients with peritoneal surface disease and the scientific principles that underlie the concept of intraperitoneal cancer therapy. It covers basic concepts such as anatomy, physiology, pharmacology, and mathematical models of drug transport as well as practical clinical applications, highlighted with results from clinical trials and promising novel preclinical developments.

Edited by

Wim P. Ceelen, MD, PhD, professor of surgery, Ghent University Hospital, Belgium

Edward Levine, MD, professor of surgery and chief of surgical oncology, Wake Forest University, Winston-Salem, USA

PERITONEUM: EMBRYOLOGY, ANATOMY, AND PHYSIOLOGY. Embryology and Anatomy of the Peritoneal Cavity. Structure and Function of the Mesothelial Cell. Applied Radiological Anatomy of the Peritoneal Cavity. Peritoneal Drug Transport. PERITONEAL CARCINOMATOSIS: BASIC MECHANISMS. Molecular Biology of Peritoneal Carcinomatosis. Dissemination and Adhesion of Peritoneal Cancer Cells to the Peritoneal Wall. Genomic Approaches to Peritoneal Carcinomatosis. Surgery, Wound Healing, and Peritoneal Minimal Residual Disease in Colorectal Cancer. Role of the Greater Omentum in the Pathogenesis of Peritoneal Carcinomatosis. Lymphatic Transport and the Diaphragmatic Stomata. INTRAPERITONEAL DRUG THERAPY: BASIC PRINCIPLES. Pharmacokinetics of Intraperitoneal Cytotoxic Drug Therapy. Tissue Transport and Pharmacodynamics of Intraperitoneal Chemotherapy. Mathematical Models of Intraperitoneal Drug Delivery. SURGICAL TECHNIQUES FOR INTRAPERITONEAL DRUG DELIVERY. Management of Peritoneal Metastases Using Cytoreductive Surgery and Perioperative Chemotherapy. Chemoperfusion Techniques and Technologies. Port Placement for Intraperitoneal Chemotherapy. CLINICAL RESULTS OF INTRAPERITONEAL DRUG DELIVERY. Intraperitoneal Chemotherapy for Ovarian Cancer. Cytoreductive Surgery and HIPEC in the Treatment of Advanced Epithelial Ovarian Cancer and Serous Papillary Peritoneal Carcinoma. Pseudomyxoma Peritonei. Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Metastatic Colorectal Cancer with Peritoneal Surface Disease. Diffuse Malignant Peritoneal Mesothelioma: Current Concepts in Evaluation and Management. Gastric Cancer and Intraperitoneal Chemotherapy. Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Peritoneal Carcinomatosis from Small Bowel Adenocarcinoma. Peritoneal Surface Malignancy from Neuroendocrine Tumors. Treatment Considerations for High-Grade Appendiceal Aden