Advances in Oncology reviews the year's most important findings and updates within the field in order to provide practicing oncologists with the current clinical information they need to improve patient outcomes. A distinguished editorial board, led by Dr. Leonidas C. Platanias, identifies key areas of major progress and controversy and invites preeminent specialists to contribute original articles devoted to these topics. These insightful overviews in oncology inform and enhance clinical practice by bringing concepts to a clinical level and exploring their everyday impact on patient care.

• Contains 25 articles on such topics as de-escalation therapy for HPV-associated oropharyngeal cancer; management of in-transit metastatic melanoma; rare gynecologic tumors; pediatric lymphoma: advances with an eye on disparities; the microbiome and CNS tumors; adjuvant therapy for patients with high-risk urothelial cancer following surgery; targeting the RAS gene for treatment of GI cancers; and more.

• Provides in-depth, clinical reviews in oncology, providing actionable insights for clinical practice.

• Presents the latest information in the field under the leadership of an experienced editorial team. Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews.

SECTION I: RADIATION ONCOLOGY

De-escalation for Human Papillomavirus-Associated Oropharyngeal Cancer: A Comprehensive Review Treatment of Endometrial Cancer: Updates and Future Directives

SECTION II: SURGICAL ONCOLOGY

Remote Telemonitoring and Telehealth in Surgical Oncology Management of In-Transit Metastatic Melanoma Contemporary Management of Merkel Cell Carcinoma

SECTION III: GYNECOLOGIC ONCOLOGY

Mitogen-Activated Protein Kinase Driven Rare Gynecologic Cancers and Evolving Therapeutic Targets Advances in Cervical Cancer

SECTION IV: PEDIATRIC ONCOLOGY

Advances in Pediatric Hodgkin Lymphoma with an Eye on Disparities and Vulnerable Populations

SECTION V: NEURO-ONCOLOGY

Advances in Blood-Brain Barrier Disruption to Facilitate Drug Delivery for Infiltrative Gliomas Updates on Role for and Efficacy of Laser Interstitial Thermal Therapy in the Management of Brain Tumors The Microbiome and Central Nervous System Tumors

SECTION VI: HEMATOLOGICAL

>Positive Acute Lymphoblastic Leukemia Inherited Predisposition to Hematopoietic Malignancies: Advances Made in the Diagnosis and Management of Hereditary Hematopoietic Malignancies in the Era of Next-Generation Sequencing Technologies

SECTION VII: URO-ONCOLOGY The Future of Radioligand Therapies in Metastatic Castrate-Resistant Prostate Cancer The Future of Antibody-Drug Conjugates in Urothelial Cancer: New Indications and Novel Targets

SECTION VIII: GASTROINTESTINAL ONCOLOGY Targeting Rat Sarcoma Viral Oncogene Homolog for Treatment of Gastrointestinal Cancers Recent Clinical Advances in Rare Gastrointestinal Tumors: Anal, Small Intestine, and Appendix Cancers Gastrointestinal Cancers and the Link to the Microbiome