In this issue of Hematology/Oncology Clinics, guest editors Drs. Edward J. Benz, Jr. and Vijay G. Sankaran bring their considerable expertise to the topic of Thalassemia. Top experts in the field provide an overview of the history, epidemiology, pathogenic mechanisms, and clinical management of the thalassemia syndromes.
- Contains 16 practice-oriented topics including molecular basis and genetic modifiers of thalassemia; fetal hemoglobin in thalassemia; clinical complications and their management; iron chelation in thalassemia; fertility and pregnancy in women with transfusion-dependent thalassemia; gene therapy and genome editing in thalassemia; emerging medical therapies for thalassemia; and more. 
- Provides in-depth clinical reviews on thalassemia, offering actionable insights for clinical practice. 
- Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews. 

Introduction to the Thalassemia Syndromes: Molecular Medicine's Index CaseThe Need for Translational Epidemiology in Beta Thalassemia Syndromes:A Thalassemia International Federation PerspectiveMolecular Basis and Genetic Modifiers of ThalassemiaFetal Hemoglobin Regulation in Beta-ThalassemiaClinical Classification, Screening, and Diagnosis in Beta-Thalassemia and Hemoglobin E/Beta-ThalassemiaThe Clinical Phenotypes of Alpha ThalassemiaPathogenic Mechanisms in Thalassemia I: Ineffective Erythropoiesis and HypercoagulabilityPathogenic Mechanisms in Thalassemia II: Iron OverloadClinical Complications and Their ManagementClinical Challenges with Iron Chelation in Beta ThalassemiaFertility and Pregnancy in Women with Transfusion-Dependent ThalassemiaHematopoietic Stem Cell Transplantation in ThalassemiaGene Therapy and Gene Editing for b-ThalassemiaEmerging Therapies in b-Thalassemia