In this issue of Clinics in Geriatric Medicine, guest editor Dr. Shamsuddin Akhtar brings his considerable expertise to the topic of Geriatric Anesthesia. Top experts in the field discuss central nervous system changes in older adults; data science and geriatric anesthesia research; aging, COVID, and perioperative care; balancing efficiency, empathy, safety, and quality; pain management in older adults; and more.