International authorities review the mechanisms and clinical implications of drug resistance in cancer.

List of contributors; Series editor's preface; Abbreviations; 1. Resistance mechanisms to antimetabolites Erdem Göker, Richard Gorlick and Joseph R. Bertino; 2. Resistance to antitumor alkylating agents and cisplatin Beverly A. Teicher and Emil Frei III; 3. The MDR genes Lyn Mickley and Antonio Tito Fojo; 4. Topoisomerase genes and resistance to topoisomerase inhibitors Giuseppe Giaccone; 5. Genes that modulate apoptosis: major determinants of drug resistance John A. Hickman; 6. Clinical implications of drug resistance Henk M. W. Verheul and Herbert M. Pinedo; 7. The reversal of multidrug resistance William S. Dalton; 8. Effect of dose and schedule on chemotherapeutic drug resistance David Fennelly, George Raptis, John P. A. Crown and Larry Norton; 9. Circumvention of drug resistance by high-dose chemotherapy in solid tumors Elisabeth G. E. de Vries, Wil Dolsma, Geke A. P. Hospers and Nanno H. Mulder; 10. Enhancing drug effectiveness by gene transfer Karol Sikora; Index.