Maurie Markman and a panel of distinguished clinicians and leading clinical investigators comprehensively review the current status of regional antineoplastic drug delivery in the management of malignant disease. These authorities present a critical analysis of both the rationale and limitations of regional therapy and discuss potential clinical trials designed to explain the effectiveness of this method of therapy in special settings. Their presentations describe many exciting and innovative strategies for using regional drug delivery in anticancer therapy, including coverage of such areas of special interest as colorectal, skin, lung, pancreatic, ovarian, and gastrointestinal cancers. Comprehensive and authoritative, Regional Chemotherapy: Clinical Research and Practice offers surgical and medical oncologists and clinical cancer investigators a gold-standard review of the current role and future development of this increasingly powerful weapon in the battle against cancer.

1 Principles of Regional Antineoplastic Drug Delivery.- 2 Intrahepatic Chemotherapy for Metastatic Colorectal Cancer.- 3 Regional Hepatic Arterial Infusion Chemotherapy forHepatic Colorectal Metastases.- 4 Regional Chemotherapy of Melanoma.- 5 Isolated Limb Perfusion for Malignant Melanoma and Soft Tissue Sarcoma.- 6 Lung Perfusion for Treatment of Metastatic Sarcoma to the Lungs.- 7 Regional Chemotherapy of Cancer of the Pancreas.- 8 National Cancer Institute Experience with Regional Therapy for Unresectable Primary and Metastatic Cancer of the Liver or Peritoneal Cavity.- 9 Surgical Considerations in Intraperitoneal Chemotherapy.- 10 Memorial Sloan-Kettering Cancer Center Experience with Intraperitoneal Chemotherapy of Ovarian Cancer.- 11 Southwest Oncology Group Experience with Intraperitoneal Chemotherapy of Ovarian Cancer.- 12 Intraperitoneal Biologic Therapy for Ovarian Cancer.- 13 Intraperitoneal Therapy with Fluoropyrimidines in the Treatment of Ovarian and Gastrointestinal Cancers.- 14 Cytoreductive Surgery and Intraperitoneal Chemotherapy for Peritoneal Surface Malignancies.- 15 Memorial Sloan-Kettering Cancer Center Experience with Intraperitoneal Chemotherapy for Gastric Cancer.- 16 Regional Therapy for Gastric Cancer with and without Peritoneal Metastasis by Intraperitoneal Hyperthermic Chemoperfusion.- 17 Intraperitoneal Chemotherapy in Management of Peritoneal Mesothelioma.- 18 Intravesical Therapy for Superficial Bladder Cancer.- 19 Principles of Intrathecal Chemotherapy.- 20 Regional Chemotherapy for Meningeal Involvement with Breast Cancer.- 21 Regional Chemotherapy for Treatment and Prophylaxis of Meningeal Lymphoma.- 22 Regional Chemotherapy for the Treatment and Prophylaxis of Meningeal Leukemia.