GENERAL. Retinal Drug Delivery. Blood Retinal Barrier. Neuroprotection. Regulatory Issues in Drug Delivery to the Eye. SPECIFIC DELIVERY SYSTEMS. Intravitreal Injection. Anti-angiogenic Agents. Intravitreal Antimicrobials. Pharmacologic Retinal Reattachment with INS37217 (Denufosol Tetrasodium), a Nucleotide P2Y2 Receptor Agonist. Cell Based Delivery Systems. Photodynamic Therapy. Thermal Sensitive Liposomes. Gene Therapy for Retinal Disease. Biodegradable Systems. Transscleral Drug Delivery to the Retina and Choroid. Nondegradable Intraocular Sustained Release Drug Delivery Devices. LOCAL DRUG DELIVERY APPROACH TO SPECIFIC CLINICAL DISEASES. Age-Related Macular Degeneration. Photodynamic Therapy Human Clinical Studies. Age-Related Macular Degeneration Drug Delivery. Intraocular Sustained Drug Delivery in Uveitis. Drug Delivery for Proliferative Vitreoretinopathy: Prevention and Treatment. Pharmacological Treatment in Diabetic Macular Edema. Retinal Vein Occlusion. Cytomegalovirus (CMV) Retinitis. Endophthalmitis