Systems Medicine introduces the topic of physiological circuits, in which cells and organs communicate. It is written in a very accessible style, suitable for anyone with a background in biology, engineering, physics, math, engineering, computer science, chemistry or other subjects.

Uri Alon is the Abisch-Frenkel Professor of Systems Biology at the Weizmann Institute of Science, Israel. https://www.weizmann.ac.il/mcb/UriAlon/homepage

Introduction. Part I Hormone Circuits. Chapter 1 The Insulin-Glucose Circuit. Chapter 2 Dynamical Compensation, Mutant Resistance, and Type-2 Diabetes. Chapter 2.5 Three Laws of Physiology. Chapter 3 The Stress Hormone Axis as a Two-Gland Oscillator. Chapter 3.5 The Thyroid and Its Discontents. Part II Immune Circuits. Chapter 4 Autoimmune Diseases as a Fragility of Mutant Surveillance. Chapter 5 Inflammation and Fibrosis as a Bistable System. Chapter 6 Basic Facts of Aging. Chapter 7 Aging and Saturated Repair. Chapter 8 Age-Related Diseases. Chapter 9 Periodic Table of Diseases. EPILOGUE: SIMPLICITY IN SYSTEMS MEDICINE. ACKNOWLEDGMENTS. INDEX.