Reflecting the breadth of modern clinical practice in this emerging therapy area, this integrated text incorporates aspects of all the relevant existing expertise, including preconceptual counseling, fertility investigation, and therapy and management of preconception through the first trimester of pregnancy. The book discusses issues surrounding high-risk patients and examines problems caused by endometriosis, poor sperm quality, and tubal disease. Outlining the management of early pregnancy, it also explores the psychological aspects of fertility therapy and reviews solutions for older women wishing to conceive.

Nicholas Macklon, Ian Greer, Eric Steegers

PRECONCEPTION 1. Genetics and Conception 2. Lifestyle and Conception 3. Preconceptual Counselling PREPARING THE HIGH-RISK PATIENT 4. The Patient with Renal Disease 5. The Patient with an Organ Transplant 6. The Patient with Hypertension 7. The Patient with Cardiac Disease 8. The Patient with Thyroid Disease 9. The Patient with Diabetes 10. The Patient with Epilepsy 11. The Patient with Thrombosis and Bleeding Disorders 12. The Patient with Polycystic Ovary Syndrome 13. The Patient with HIV 14. The Patient with Cystic Fibrosis 15. The Patient with Inflammatory Bowel Disease 16. The Patient with Prolactinoma 17. Periconceptional Issues in Neuromuscular Disorders. 18. The Patient with or at Risk of Severe Mental Illness ACHIEVING PREGNANCY 19. How to Conceive: Evidence Based Fertility Investigation 20. The Anovulatory Patient 21. The Patient with Endometriosis 22. The Patient with Poor Sperm Quality 23. The Patient with Tubal Disease 24. The Couple with Unexplained Infertility 25. The Patient from the Developing World 26. Older Woman Wishing to Conceive 27. Psychological Aspects of Fertility Therapy 28. The Luteal Phase 29. Implantation Failure MANAGEMENT OF EARLY PREGNANCY 30. Early Placental Development 31. The Immunology of Early Pregnancy 32. Mechanisms and Nomenclature of Early Pregnancy Loss 33. Antiphospholipid Syndrome, Heritable Thrombophilia and Early Pregnancy Loss 34. Ultrasound in Early Pregnancy 35. Evidence Based Investigation and Management of Miscarriage 36. Ectopic Pregnancy after Fertility Treatment 37. Molar Pregnancy 38. Multiple Pregnancy 39. Cervical Cerclage and Pregnancy Loss 40. The IVF Pregnancy: High Risk Management?