Eighteen contributions consider various aspects of pulmonary vascular control and the pulmonary vasculature's response to injury and disease. They discuss recent advances in molecular biology to cell proliferation, interactions between the endothelium and smooth muscle, and the etiologies of various

E. Kenneth Weir Department of Medicine, VA Medical Centre and University of Minnesota, John T. Reeves CVP Research Laboratory, University of Colorado, Health Sciences Center, Denver, Series Editor Claude Lenfant

Part I PHYSIOLOGY 1. A Phylogenetic Perspective of Control of the Pulmonary Circulation 3 2. Control of Fetal and Neonatal Pulmonary Circulation 3. Pressure and Flow in the Pulmonary Vascular Bed 4. Pulmonary Circulation During Exercise 5. Circulation in the Pregnant and Nonpregnant State 6. Hypobaric Effects on the Pulmonary Circulation and High-Altitude Pulmonary Edema 7. Pulmonary Circulation in Diving and Hyperbaric Environment 8. Mechanisms of Acute Hypoxic and Hyperoxic Changes in Pulmonary Vascular Reactivity 9. Autonomic Control of the Pulmonary Circulation 10. Right Ventricular Function in Pulmonary Hypertension Part II PATHOPHYSIOLOGY 11. Etiologic Mechanisms in Persistent Pulmonary Hypertension of the Newborn 12. Pulmonary Circulatory Control in Lung Injury 13. Role of Humoral Mediators in the Pulmonary Vascular Response to Pulmonary Embolism 14. Mechanisms of Pulmonary Hypertension in Chronic High F1ow States 16. Etiologic Mechanisms in Primary Pulmonary Hypertension 17. The Interaction Between Polymorphonuclear Cells and Pulmonary Endothelium: Nonnal Kinetics and the Pathogenesis of Acute Lung Injury 18. The Potential Role of Interactions Between Endothelium and Smooth Muscle in Pulmonary Vascular Physiology and Pathophysiology