This reference book covers non-shivering thermogenesis, metabolic rates, and associated diseases.It emphasizes the phylogenetic relations of vertebrate non-shivering thermogenesis, regulatory mechanisms, and evolutionary significance.It discusses non-shivering thermogenesis in birds and wild animals, and muscle adaptation during hibernation.

Dr. Naresh Chandra Bal

Associate Professor

KIIT School of Biotechnology

Campus-11, KIIT University

Bhubaneswar, Odisha

Dr. Bal has more than 15 years of research experience in muscle and brown adipose tissue (BAT) thermogenesis. He also possesses more than 20 years of teaching experience in physiology and biochemistry related subjects at different levels. He has designed and performed studies on several transgenic mouse models using manipulation of thermogenic capacities of both the sites: BAT and muscle. In addition to these transgenic models he has also employed other strategies like pharmacological, surgical and diet-intervention to address questions related to thermogenesis, especially nonshivering thermogenesis (NST). He has authored more than 30 manuscripts on this topic including top-tier journals such as Nature Medicine, Trends in Endocrinology and Metabolism, Biological Reviews, Journal of Biological Chemistry (JBC), and Biochemical Journal. He has published 60 journal articles in total and his papers have been cited by top researchers in the field from all over the world. Currently, his H-index is 30 with total citation of more than 3000. For his pioneering research, he has been awarded with several honors including Physiological Genomics Fellowship, American Physiological Society (APS), USA; K01 Award from National Institute of Health (NIH), USA; Ramalingaswami Re-entry Fellowship, Government of India; Early Career Research Award, Government of India. He serves as associate editor in Frontiers in Physiology and editor in Metabolites & Molecular Medicine Reports. Due to his scientific contribution he has been elected as the Fellow of the Royal Society of Biology, UK.

Ms. Punyadhara Pani

Senior Research Fellow

KIIT School of Biotechnology

Campus-11, KIIT University

Bhubaneswar, Odisha

Ms. Punyadhara Pani is currently working in the laboratory of Dr. Bal in delineating molecular mechanisms of muscle nonshivering thermogenesis (NST) in birds. She completed her bachelors from Utkal University and masters from Ravenshaw University with Summa-cum-Laude. She served as a teacher and taught undergraduate students for about five years. Due to her excellent academic distinctions, she has been awarded with one of the most competitive pre-doctoral research funding called DST-Inspire fellowship from the Government of India. She is admirable in writing and has bagged first prize in several state-level competitions. She designed and developed her manuscripts which have been published in several renowned journals like Biological reviews, Biochemical Journal etc. Moreover, she has successfully presented her work in the form of poster and oral presentations in both National and International conferences for which she has got recognition and awards. She has done extensive research on skeletal muscle adaptation to environmental factors, pharmacological agents and cytokines leading to several recent publications in internationally reputed journals. For these studies, she has used different animal models including mammalian and avian providing biochemical/genetic insight for NST in the muscle.

Unit 1: NONSHIVERING THERMOGENESIS THROUGH BROWN FAT AND ALLIED MECHANISMS. 1. Evolutionary and developmental origin of brown adipose tissue. 2.Molecular mechanisms of heat production in brown adipose tissue. 3.Neurohormonal regulation of heat production in brown adipose tissue. 4.Thermogenic Determinants in Hibernation Models. Unit 2: SKELETAL MUSCLE NONSHIVERING THERMOGENESIS: EVOLUTIONARY, MECHANISTIC AND ECOLOGICAL ASPECTS. 5. Endothermy in Fishes: A Remarkable Story of Convergent Evolutionary Adaptation. 6. Whole-body endothermy and non-shivering thermogenesis (NST) in today's birds and mammals and in their past. 7. Non-shivering thermogenesis in birds: A role for skeletal muscle. 8. Ryanodine Receptor 1 calcium leak in non-shivering thermogenesis. 9. Futile SERCA-mediated calcium cycling activity as the basis for non-shivering thermogenesis in the skeletal muscle. 10.Recruitment of non-shivering thermogenesis in skeletal muscle: Importance of environmental context. Unit 3: BIOMEDICAL RELEVANCE OF NONSHIVERING THERMOGENESIS. 11. Targeting mitochondrial energy efficiency to treat chronic metabolic diseases. 12. Muscle-based thermogenesis and its physiological implications for obesity and muscle health. 13. Recruitment of brown and beige adipose tissue thermogenesis through muscular activity. 14. Phytochemicals as potential candidates to combat obesity via non-shivering thermogenesis.