Understand and assess the design, delivery, and efficacy oforally administered drugs
A practical guide to understanding oral bioavailability, one ofthe major hurdles in drug development and delivery, OralBioavailability: Basic Principles, Advanced Concepts, andApplications is designed to help chemists, biologists, life scienceresearchers, pharmaceutical scientists, pharmacologists,clinicians, and graduate and students become familiar with thefundamentals and practices of the science of oralbioavailability.
The difference in rate and extent between a drug taken orallyand the actual amount of a drug reaching the circulatory system,oral bioavailability is an essential parameter for determining theefficacy and adverse effects of new and developing medications, aswell as finding an optimal dosing regimen.
This book provides a much-needed one-stop resource to helpreaders better understand and appreciate the many facets andcomplex problems of oral bioavailability, including the basicbarriers to oral bioavailability, the methods used to determinerelevant parameters, and the challenges of drug delivery.
In addition, this comprehensive book discusses biological andphysicochemical methods for improving bioavailability, integratesphysicochemistry with physiology and molecular biology, andincludes several state-of-the-art technologies andapproaches--Caco-2 cell culture model, MDCK, and other relatedcell culture models--which are used to study the science oforal bioavailability.