This comprehensive and readable overview provides an excellent starting point for undergraduate and graduate students.

Using model organisms from the three domains of life (Bacteria, Archaea, and Eukarya), Genome Duplication describes the principal molecular mechanisms of DNA replication and shows how the process is linked to cell division. This approach allows the authors to shed insight into how genome duplication has evolved, and how its regulation is relevant to the understanding and treatment of human disease, especially cancer.

DePamphilis, Melvin; Bell, Stephen

1. Genomes
2. Three Domains of Life
3. Replication Forks
4. Replication Proteins: Leading-Strand Synthesis
5. Replication Proteins: Lagging-Strand Synthesis
6. Termination
7. Chromatin Assembly, Cohesion, and Modification
8. Replicons
9. Replication Origins
10. Origin Paradigms
11. Initiation
12. Cell Cycles
13. Checkpoints
14. Human Disease
15. Evolution of Cellular Replication Machines