The overarching research topic addressed in this book is the complex and multifaceted interaction between infrastructural accessibility/connectivity of city-regions on the one hand and knowledge generation in these city-regions on the other hand. To this end, the book brings together chapters analysing how infrastructural accessibility is related to changing patterns of business location of knowledge-intensive industries in city-regions. The chapters in this book specifically dwell on recent manifestations of, and developments in, the accessibility/knowledge-nexus, with a particular metageographical focus on how this materializes in major city-regions.

Introduction Knowledge Hubs, BenDerudder, SvenConventz, AlainThierstein, FrankWitlox; Part I PART I; Chapter 1 Knowledge Flows and Physical Connectivity in the Global Economy, BenDerudder, Elien VanDe Vijver, FrankWitlox; Chapter 2 Knowledge Hubs, MichaelBentlage, AlainThierstein, StefanLüthi; Chapter 3 Knowledge Hubs in the Polycentric German Urban System between Concentration Processes and Conurbation Dynamics, AnnaGrowe; Chapter 4 Hub-airports as Cities of Intersections, SvenConventz, AlainThierstein; Chapter 5 European Port Cities, AnneWiese, AlainThierstein; Part II PART II; Chapter 6 Hub Cities in the Evolving Internet, Edward J.Malecki; Chapter 7 Urban and Regional Analysis and the Digital Revolution, EmmanouilTranos, PeterNijkamp; Chapter 8 Mediating the City, OliMould; Part III PART III; Chapter 9 Agglomeration and Knowledge in European Regional Growth, TeodoraDogaru, Frankvan Oort, DarioDiodato, MarkThissen; Chapter 10 Types of Hub Cities and their Effects on Urban Creative Economies, Zachary P.Neal; Chapter 11 Capital Cities as Knowledge Hubs, HeikeMayer, MargaretCowell;

Sven Conventz, Munich University of Technology, Germany, Ben Derudder, Ghent University, Belgium; Alain Thierstein, Munich University of Technology, Germany and Frank Witlox, Ghent University, Belgium.