Earth's Mightiest Heroes face their greatest challenges! First, when She-Hulk is declared a global menace, Russia's champions the Winter Guard are tasked with bringing her to justice! But when Jen Walters enters the Red Room, something terrifying emerges! Then, from outside our reality come the Deathloks, with a dire warning. The Multiversal Masters of Evil are coming - and with both Asgard and Avengers Mountain under assault, powerful new allies must assemble! Welcome to Namor the Sub-Mariner and Jane Foster, A.K.A. Valkyrie! But surely Starbrand is too young to be an Avenger? Meanwhile, what is Nighthawk up to? And when Mephisto's grand plan nears fruition, our time-torn heroes will need help from legendary champions from different eras whose stories have never been told - until now! Collecting AVENGERS (2018) #46-62, AVENGERS 1,000,000 BC #1 and material from FREE COMIC BOOK DAY 2021: AVENGERS/HULK.