This book describes the new developments for the analysis of quantal response data, and emphasizes the links between the various different areas. The main emphasis in the examples which illustrate the methodology will be on the evaluation and testing of substances, mainly drugs, for use in humans.

1. Data, preliminary analyses and mechanistic models 2. Maximum-likelihood fitting of simple models 3. Extensions and alternatives 4. Extended models for quantal assay data 5. Describing time to response 6. Over-dispersion 7. Non-parametric and robust methods 8. Design and sequential methods