Reviewing the increased scientific data available on foot-and-mouth disease (FMD), this comprehensive volume keeps researchers up-to-date with all the latest developments. Interdisciplinary in approach, this book is the first to provide a coherent picture of the emerging strategies for diagnosis and control.

Esteban Domingo, Francisco Sobrino

Stepping stones in foot-and-mouth research: A personal view. Genome organization, translation and replication of foot-and-mouth disease virus RNA. Foot-and-mouth disease virus proteinases. Structure of foot-and-mouth disease virus particles. Clinical signs of foot-and-mouth disease. Persistence of foot-and-mouth disease virus. Molecular aspects of foot-and-mouth disease virus virulence and host range: Role of host cell receptors and viral factors. Immunology of foot-and-mouth disease. Functional and structural aspects of the interaction of foot-and-mouth disease virus with antibodies. Quasispecies dynamics and evolution of foot-and-mouth disease virus. Modern inactivated foot-and-mouth disease (FMD) vaccines: Historical background and key elements in production and use. Foot-and-mouth disease virus peptide vaccines. Mathematical models of the epidemiology and control of foot-and-mouth disease. Natural habitats in which foot-and-mouth disease viruses are maintained. Diagnosis and control of foot-and-mouth disease. Control of foot-and-mouth disease: Role of international organizations. Overview of foot-and-mouth disease and its impact as a re-emergent viral infection.