This introductory book broadly covers the foundations, principles, and methodologies of single molecule fluorescence and force probe techniques as applied to the most important and timely biological problems, providing a first introduction to key concepts and highlights the advantages and pitfalls of each of these exciting emerging methods.

Yuri L. Lyubchenko is Professor of Pharmaceutical Sciences at the University of Nebraska Medical Center, Omaha, NE, USA. His research focuses on understanding fundamental mechanisms underlying health and disease, which are key to developing new and more effective diagnostics and medications. This primarily basic research allows him not only identify new drug targets for small molecule drugs, it also leads to development of the nanotools and methods to discover novel approaches for diagnostic, treatment, and disease prevention, and to more rapidly determine their efficacy at the molecular level.

1. Single Molecule Fluorescence

Ashok Deniz

2. Atomic Force Microscope for Topographic Studies

Yuri L. Lyubchenko

3. Atomic Force Microscope Force Spectroscopy

Eric A. Josephs, Piotr E. Marszalek, and Zackary N. Scholl

4. Magnetic Tweezers

Piero R. Bianco, Yuri L. Lyubchenko, and Zhiqiang Sun

5. Optical Tweezers

Marco Capitanio

6. Nanofluidic Transport and Sensing in Biological and Artificial Nanopores

Aleksandr Noy and Meni Wanunu