Microfluidics-based biochips combine electronics with biochemistry for emerging application areas such as point-of-care medical diagnostics, on-chip DNA analysis, automated drug discovery, and protein crystallization. This book envisions an automated design flow for microfluidic biochips. It offers automation solutions for problems unique to digital microfluidics. The authors provide a comprehensive methodology for the automated design, test, and use of robust and low-cost manufactured digital microfluidic systems. Using real-life bioassays as examples, they offer a comprehensive set of practical methodologies and tools for chip design and manufacture.

Krishnendu Chakrabarty is a Professor of Electrical and Computer Engineering at Duke University and a Chair Professor of Software Theory at Tsinghua University, Beijing, China. Tao Xu is a DFT Engineer at Cisco Systems, Inc.

Introduction. Defect-Tolerant and Routing-Aware Synthesis. Pin-Constrained Biochip Design. Testing and Diagnosis. Design for Testability. Application on Protein Crystallization. Conclusions. References.