The purpose of this book is to examine the etiology of cancer in large human populations using mathematical models developed from an inter-disciplinary perspective of the population epidemiological, biodemographic, genetic and physiological basis of the mechanisms of cancer initiation and progression. In addition an investigation of how the basic mechanism of tumor initiation relates to general processes of senescence and to other major chronic diseases (e.g., heart disease and stroke) will be conducted.

Preface.- Introduction: Cancer contra human: cohabitation with casualties?- Cancer modeling: how far can we move?- Cancer risk factors.- Standard and innovative statistical methods for empirically analyzing cancer morbidity and mortality.- Stochastic methods of analysis.- U.S. cancer morbidity and mortality risks.- U.S. cancer morbidity: modeling age-patterns of cancer histotypes.- Risk factors intervention.- Cancer prevention.- Conclusion/outlook.- Appendices.