"Lymphocyte Development" presents an extremely up-to-date account of
molecular processes involved in the development of lymphocytes. This
well written book is based on a graduate course taught by the author.
Topics include the selection processes involved in lymphocyte
maturation, immune receptor gene rearrangement, signaling pathways
involved in cell cycle progression and apoptosis, and the
transcriptional regulation of lymphoid ontogeny. The book also covers
T cell development and differentiation of helper and cytotoxic T cells
as well as the development of Natural Killer lymphocytes. The book
finishes with an account of the molecular basis of immunodeficiency
syndromes. It will interest researchers in immunology and it will be
useful as a supplementary text for a graduate level immunology
course.

1 Overview of Cell Fate Decisions During Lymphoid Ontogeny.- 2 Commitment to a Lymphoid Fate.- 3 V(D)J Recombination and the Generation of Diversity.- 4 Pathways Mediating Signal Transduction and Cell Cycle Progression in Lymphocytes.- 5 Molecular Mechanisms of Lymphocyte Apoptosis.- 6 Lymphocyte Homing and the Generation of Secondary Lymphoid Organs.- 7 The Generation of Naive B Lymphocytes.- 8 Antigen-Induced B-Lymphocyte Differentiation.- 9 T Lymphocyte Development.- 10 The Activation and Differentiation of Mature T Lymphocytes.- 11 The Development of Natural Killer Cells.- 12 Naturally Occurring Disorders of Lymphocyte Development.