This work shows how the cellular Potts model can be used as a framework for model building and how extended models can achieve better biological practicality, accuracy and predictive power. It focuses on ways to integrate and interface the cellular Potts model at the mesoscopic scale with approaches that accurately model microscopic dynamics.

Marco Scianna is a post-doctoral fellow in the Department of Mathematical Sciences at the Politecnico di Torino. He earned a Ph.D. in complex systems in post-genomic biology from the University of Turin. His principal research focuses on mathematical multiscale models applied to biological and biomedical problems, with particular interest in the context of tumor growth, vascular network formation, and cell migration in extracellular matrix.

Luigi Preziosi is a professor of mathematical physics at the Politecnico di Torino. He earned a Ph.D. in mechanics from the University of Minnesota and in mathematics from the University of Naples. He has authored three books, more than 30 book chapters, and more than 100 articles in international journals. His recent research interests include multiphase models of tumor growth, the mechanics of tissue growth and regenerations, cell migration, and vascular network formation.

I Basic Cellular Potts Model and Applications: Basic CPM. HGF-Induced Cell Scatter. Mesothelial Invasion of Ovarian Cancer. II Extended Cellular Potts Model and Applications: Extended Cellular Potts Model. Wound Healing Assay. Effect of Calcium-Related Pathways on Single Cell Motility. Tumor-Derived Vasculogenesis. Different Morphologies of Tumor Invasion Fronts. Cell Migration in Extracellular Matrices. Cancer Cell Migration in Matrix Microchannels. Appendices. Bibliography. Index.