This book represents an updated review of the physiology of the carotid body chemoreceptors. It contains results in the topics at the frontiers of future developments in O2-sensing in chemoreceptor cells. Additionally, this volume provides data from studies carried out in other O2-sensing tissues including pulmonary vasculature and erythropoietin producing cells. It is a prime source of information and a guideline for arterial chemoreception researchers.

CONTENTS A Tribute to Professor Autar Singh Paintal: Ravi K. and Vijayan V.K. Structure of Chemoreceptors Immunolocalization of Tandem Pore Domain K+ Channels in the Rat Carotid Body: Yamamoto Y., Taniguchi K. Neuroglobin, a New Oxygen Binding Protein is Present in the Carotid Body and Increases after Chronic Intermittent Hypoxia: Giulio C., Bianchi G., Cacchio M., Artese L., Piccirilli M., Verratti V., Valerio R., Iturriaga R. Hypoxia-Inducible Factor (HIF)-1a and Endothelin-1 Expression in the Rat Carotid Body during Intermittent Hypoxia: Lam S-Y., Tipoe G.L., Liong E.C., Fung M-L. Expression of HIF-2a and HIF-3a in the Rat Carotid Body in Chronic Hypoxia: Lam S-Y., Liong E.C., Tipoe G.L., Fung M-L. Modulation of Gene Expression in Subfamilies of TASK K+ Channels by Chronic Hyperoxia Exposure in Rat Carotid Body: Kim I., Donnelly D.F., Carroll J.L. Postnatal Changes in Gene Expression of Subfamilies of TASK K+ Channels in Rat Carotid Body: Kim I., Kim J.H., Carroll J.L. Morphological Changes in the Rat Carotid Body in Acclimatization and Deacclimatization to Hypoxia: H., Hirakawa H., Oikawa S., Hayashida Y., Kusakabe T. Effect of Carbon Dioxide on the Structure of the Carotid Body: A Comparison between Normoxic and Hypoxic Conditions: Kusakabe T., Hirakawa H., Oikawa S., Matsuda H., Hayashida Y. S-Nitrosoglutathione (SNOG) Accumulates Hypoxia Inducible Factor-1a in Main Pulmonary Artery Endothelial Cells but not in Micro Pulmonary Vessel Endothelial Cells: Fujiuchi S., Yamazaki Y., Fujita Y., Nishigaki Y., Takeda A., Yamamoto Y., Fijikane T., Shimizu T., Osanai S., Takahashi T., Kikuchi K. Changes in Antioxidant Protein SP-22 of Chipmunk Carotid Bodies during the Hibernation Season: K., Wu Y., Nanri H., Ikeda M., Hayashida Y., Yoshizaki K., Ohtomo K. Potential Role of Mitochondria in Hypoxia Sensing by Adrenomedullary Chromaffin Cells: Buttigieg J., Zhang M., Thompson R., Nurse C. Localization of Ca/Calmodulin-Dependent Protein Kinase I in the Carotid Body Chief Cells and the Ganglionic Small Intensely Fluorescent (SIF) Cells of Adult Rats: Hoshi H., Sakagami H., Owada Y., Kondo H. Developmental Aspects of Chemoreceptors Dual Origins of the Mouse Carotid Body Revealed by Targeted Disruption of Hoxa3 and Mash1: Kameda Y. Genetic Regulation of Chemoreceptor Development in DBA/2J and A/J Strains of Mice: Balbir A., Okumura M., Schofield B., Coram J., Tankersley C.G., Fitzgerald R.S., O¿Donnell C.P., Shirahata M. Genetic Influence on Carotid Body Structure in DBA/2J and A/J Strains of Mice: Yamaguchi S., Balbir A., Okumura M., Schofield B., Coram J., Tankersley C.G., Fitzgerald R.S., O¿Donnell C.P., Shirahata M. The Effect of Hyperoxia on Reactive Oxygen Species (ROS) in Petrosal and Nodose Ganglion Neurons during Development (Using Organotypic Slices): Kwak D.J., Kwak S.D., Gauda E.B. Carotid Body Volume in Three-Weeks-Old Rats Having an Episode of Neonatal Anoxia: Saiki C., Makino M., Matsumoto S. The Effect of Development on the Pattern of A1 and A2a-Adenosine Receptor Gene and Protein Expression in Rat Peripheral Arterial Chemoreceptors: Gauda E.B., Cooper R.Z., Donnelly D.F., Mason A., McLemore G.L. A Comparative Study of the Hypoxic Secretory Response between Neonatal Adrenal Medulla and Adult Carotid Body from the Rat: Rico A.J., Fernandez S.P., Prieto-Lloret J., Gomez-Nino A., Gonzalez C., Rigual R. Molecular Biology of Chemoreceptors In Search of the Acute Oxygen Sensor: Functional Proteomics and Acute Regulation of Large-Conductance, Calcium-Activated Potassium