This book systematically addresses all the major available direct and enabling technologies which have contributed to the revolutionized research and development, thus improvements to existing vaccines. Its target audience is both research and development workers in the field, as well as health-care personnel who use vaccines. It should serve as an

Ronald W. Ellis, BioChem Pharma (to become Shire Biologies after soon-expected merger) Northborough, Massachusetts, U.S.A.

Preface 1. New Technologies for Making Vaccines 2. Clinical Issues for New Technologies 3. Regulatory Issues 4. In-Licensing Issues and Vaccine Technologies 5. Live Vaccines 6. Recombinant Live Attenuated Viral Vaccines 7. Live Viral Vectors 8. Inactivated Virus Vaccines 9. Live Attenuated Bacterial Vaccines 10. Live Attenuated Bacterial Vectors 11. Protein-Based Vaccines 12. Peptide Vaccines 13. Polysaccharide Vaccines 14. DNA Vaccines 15. Plant-Derived Vaccines 16. Biological Aspects and Prospects for Adjuvants and Delivery Systems 17. Transcutaneous Immunization