James E. Crowe, Jr. is an immunologist and board-certified pediatric infectious diseases specialist. Dr. Crowe is the Ann Scott Carell Chair and Professor of Pediatrics, Pathology, Microbiology and Immunology, and Director of the Vanderbilt Vaccine Center. He is an Elected Member of the Institute of Medicine and a Fellow of the American Association for the Advancement of Science, the American Academy of Microbiology, and the American Society for Clinical Investigation. Dr. Crowe's laboratory has a broad portfolio of work in the area of viral immunology and cell biology focused on discovery of the genetic and structural determinants of neutralization of viruses by human antibodies and immune mechanisms important to development of new vaccines.
Diana Boraschi is the Research Director at the CNR Institute of Protein Biochemistry. She is actively involved in high education activities, in particular in Africa. Dr. Boraschi's studies focus on the role of macrophages and IL-1 cytokines in the innate/inflammatory response against infections and tumors and their possible involvement in chronic inflammatory and autoimmune pathologies.
Rino Rappuoli is the Global Head of Research and Development at Novartis Vaccines. Dr. Rappuoli has worked on several molecules that became part of, or are near to becoming, licensed vaccines. He is an elected member of the U.S. National Academy of Sciences and of the European Molecular Biology Organization.

Contributors
Preface
Introduction
1 History and Practice: Antibodies in Infectious Diseases
General Features of Immunoglobulins
2 Functions of Antibodies
3 Antibody Structure
4 The Role of Complement in Antibody Therapy for Infectious Diseases
5 Immunoglobulin E and Allergy: Antibodies in Immune Inflammation and Treatment
Antibody Discovery Approaches
6 Phage and Yeast Display
7 Efficient Methods To Isolate Human Monoclonal Antibodies from Memory B Cells and Plasma Cells
8 Use of Human Hybridoma Technology To Isolate Human Monoclonal Antibodies
9 Humanized Mice for Studying Human Immune Responses and Generating Human Monoclonal Antibodies
10 Antibodies: Computer-Aided Prediction of Structure and Design of Function
Pathogen-Specific Antibodies
11 Antibodies Targeting the Envelope of HIV-1
12 Committing the Oldest Sins in the Newest Kind of Ways--Antibodies Targeting the Influenza Virus Type A Hemagglutinin Globular Head
13 Prevention of Respiratory Syncytial Virus Infection: From Vaccine to Antibody
14 Human Metapneumovirus
15 Dengue Antibody-Dependent Enhancement: Knowns and Unknowns
16 Immunotherapeutic Approaches To Prevent Cytomegalovirus-Mediated Disease
17 Rotavirus
18 Bacterial Toxins--Staphylococcal Enterotoxin B
Technical Advances
19 Antibody Engineering
20 High-Throughput DNA Sequencing Analysis of Antibody Repertoires
21 Antibody Informatics: IMGT, the International ImMunoGeneTics Information System Strains
22 Probing Antibody-Antigen Interactions
23 Radiolabeled Antibodies for Therapy of Infectious Diseases
Alternate Systems for Expression
24 Plant-Derived Monoclonal Antibodies for Prevention and Treatment of Infectious Disease
25 Vector-Mediated In Vivo Antibody Expression
Index