Part I. Historical Perspective

Hematopoietic Stem Cell Transplantation: A Historical Perspective
Frederick R. Appelbaum

Part II. Disease Indications: Allogeneic Transplantation

Allogeneic Hematopoietic Cell Transplantation for Adult Patients with Acute Myelogenous Leukemia
Henry C. Fung and Stephen J. Forman

Allogeneic Stem Cell Transplantation for Adult Acute Lymphoblastic Leukemia
Partow Kebriaei and Wendy Stock

Chronic Myelogenous Leukemia
Edward Copelan

Allogeneic Stem Cell Transplantation for Breast Cancer
Abby B. Siegel and Linda T. Vahdat

Allogeneic Transplantation for the Treatment of Multiple Myeloma
Stefano Tarantolo and Philip J. Bierman

Non-Hodgkin's Lymphoma
Igor Espinoza-Delgado and Dan L. Longo

Part III. Allogeneic Graft Selection

Blood vs Marrow Allogeneic Stem Cell Transplantation
Daniel Anderson and Daniel Weisdorf

Haploidentical Stem Cell Transplantation
Hillard M. Lazarus and Jacob M. Rowe

Umbilical Cord Blood Transplantation
Juliet Barker and John E. Wagner

Mesenchymal Stem Cells in Allogeneic Transplantation
Omer N. Koç and Stanton L. Gerson

Cytokines in Allogeneic Stem Cell Mobilization
Ravi Vij, Randy Brown, and John F. DiPersio

Nonmyeloablative Allogeneic Transplantation
David A. Rizzieri and Nelson J. Chao

Part IV. Supportive Care in Allogeneic Transplantation

Recent Developments in Epidemiology and Management of Invasive Fungal Infections
Andreas H. Groll and Thomas J. Walsh

Immune Recovery Following Allogeneic Blood Transplantation: Mechanisms of Immune Dysfunction
James E. Talmadge

Grading and Management of Graft-vs-Host Disease
Donna Przepiorka

Posttransplant EBV-Associated Disease
Thomas G. Gross and Brett J. Loechelt

PartV. Prevention and Management of Relapse After Allogeneic Transplantation

Allogeneic Antitumor Vaccine Strategies
Ginna G. Laport and Carl H. June

Donor Leukocyte Infusions
Robert H. Collins, Jr.

Second Hematopoietic Stem Cell Transplantation for the Treatment of Graft Failure, Graft Rejection, or Relapse
Steven N. Wolff

Part VI. Preclinical Studies in Allogeneic Transplantation

The Role of T Cell Depletion in Bone Marrow Transplantation
Yair Reisner and Massimo F. Martelli

Minimal Residual Disease in Allogeneic Recipients
Jerald P. Radich

Nonhuman Primate Models of Hematopoietic Stem Cell Transplantation
Steven M. Devine and Ronald Hoffman

In Vivo Models for the Study of Graft-vs-Host Disease and Graft-vs-Tumor Effects
Kai Sun, William J. Murphy, and Lisbeth A. Welniak

Allogeneic Effector Cell Populations: Separating GVL from GVHD
Michael R. Verneris and Robert S. Negrin

Dendritic Cells: Immunobiology and Potential Use for Cancer Immunotherapy
David Avigan

Part VII. Epilogue

Epilogue, James R. Mason and Ernest Beutler

Index

Internationally recognized physicians and researchers review both the basics of allogeneic stem cell transplantation and recent advances in the field, particularly as they relate to antitumor effects and graft-versus-host disease They also provide unique decision-tree analyses to guide clinicians in selecting and managing their allogeneic transplant patients. The innovations discussed cover a variety of areas, ranging from stem cell mobilization in normal donors, to indications for allogeneic transplantation other than hematologic malignancies, to the use of nonmyeloablative conditioning regimens. The authors also explore new developments in the optimal selection of unrelated allogeneic grafts (e.g., matched unrelated donor, partially mismatched family member, or umbilical cord blood), the use allogeneic peripheral blood stem cell vs marrow-derived grafts for transplantation, and the kinetics of immune reconstitution after transplantation.