Head and Neck Squamous Cell Cancers in the Nonsmoker-Nondrinker
Gypsyamber D'Souza and Maura L. Gillison

Laryngeal Preservation Surgery
Joseph Scharpf and Robert R. Lorenz

Laser Surgery for Head and Neck Cancer
Lee M. Akst and Marshall Strome

The Evolving Role of Neck Dissection in the Era of Organ Preservation Therapy for Head and Neck Squamous Cell Carcinoma
Tung T. Trang and Pierre Lavertu

Salvage Surgery After Chemoradiation Therapy
Walter T. Lee and Ramon M. Esclamado

T3-T4 Squamous Cell Carcinoma of the Larynx Treated With Radiation Therapy Alone or Combined With Adjuvant Chemotherapy
William M. Mendenhall

Role of Brachytherapy in Treatment of Head and Neck Malignancy
Ravi A. Shankar, Kenneth S. Hu, and Louis B. Harrison

Intensity-Modulated Radiation Therapy in the Management of Head and Neck Cancer
Theodore S. Hong, Wolfgang A. Tomé, and Paul M. Harari

Altered Fractionation: Benefits, Pitfalls With IMRT Dosimetry, and Combined Gains With Molecular Targeting
Anesa Ahamad, David I. Rosenthal, and K. Kian Ang

The Role of Tumor Hypoxia in Head and Neck Cancer Radiotherapy
Quynh-Thu Le, Amato J. Giaccia, and J. Martin Brown

Induction Chemotherapy in Head and Neck Cancer: A Critical Review of 25 Years of Clinical Trials
Danny Rischin

The Evolution of Induction Chemotherapy in Locally Advanced Squamous Cell Cancer of the Head and Neck: The New Paradigm of Sequential Therapy
Marshall R. Posner, Lori Wirth, Roy B. Tishler, Charles M. Norris, and Robert I. Haddad

Concurrent Chemoradiotherapy: Impact on Survival and Organ Preservation
David J. Adelstein

Postoperative Treatment of Locally Advanced Head and Neck Cancers
Jacques Bernier and Søren M. Bentzen

Multimodality Management of Nasopharyngeal Carcinoma
Eng-Huat Tan, Swan-Swan Leong,Terence Tan, Kam-Weng Fong, and Joseph Wee

Strategies for Protecting Normal Tissue in the Treatment of Head and Neck Cancer
David M. Brizel

Targeted Therapies in Head and Neck Cancer
Tanguy Y. Seiwert and Ezra E. W. Cohen

Gene Therapy for Patients With Head and Neck Cancer
Andrew Iskander and George H. Yoo

Chemoprevention in Head and Neck Cancer
Nabil F. Saba and Fadlo R. Khuri

Quality of Life Outcomes in Head and Neck Cancer
Allen C. Sherman, Ehab Hanna, and Stephanie Simonton

Palliation of Head and Neck Cancer
Mellar P. Davis

Index

Leading expert physicians and investigators from around the world review the state-of-the-art in the management of squamous cell head and neck cancer, with emphasis on coordinating different treatment modalities. The authors address several surgical issues, including laser-based surgery, larynx preservation approaches, salvage surgery, and neck management after non-operative treatment. They also discuss definitive radiation for larynx cancer, brachytherapy, altered fractionation radiation, intensity modulated radiation therapy, and the importance of tumor hypoxia, as well as the role of chemotherapy in sequential, concurrent, and adjuvant multi-modality treatment schedules. Other topics of special interest include targeted and gene therapies, multimodality management of nasopharyngeal cancer, chemoprevention, toxicity modification, quality of life outcomes, symptom palliation, and epidemiology.