Table of Contents 1. The Integration of Personalized and Systems Medicine: Bioinformatics Support for Pharmacogenomics and Drug Discovery Qing Yan 2. Applications of Microarrays and Biochips in Pharmacogenomics Gary Hardiman 3. Confounding in Genetic Association Studies and Its Solutions Donglei Hu and Elad Ziv 4. Pharmacogenetics of Membrane Transporters: A Review of Current Approaches Tristan M. Sissung, Erin R. Gardner, Rui Gao, William D. Figg 5. Pharmacogenomics of Drug Metabolizing Enzymes and Drug Transporters in Chemotherapy Tessa M. Bosch 6. Pharmacogenomics of G Protein-coupled Receptor Signaling: Insights from Health and Disease Miles D. Thompson, David E.C. Cole and Pedro A. Jose 7. G Protein-coupled Receptors Disrupted in Human Genetic Disease Miles D. Thompson, Maire E. Percy, W. McIntyre Burnham, and David E.C. Cole 8. G Protein-coupled Receptor Pharmacogenetics Miles D. Thompson, Katherine A. Siminoivitch, and David E.C. Cole 9. Epigenetic Alterations of the Dopaminergic System in Major Psychiatric Disorders Hamid Mostafavi Abdolmaleky and Sam Thiagalingam 10. Pharmacogenomics in Alzheimer's Disease Ramón Cacabelos 11. Pharmacogenetics of Asthma Gregory A. Hawkins and Stephen P. Peters 12. From SNPs to Functional Studies in Cardiovascular Pharmacogenomics Sharon Cresci 13. Pharmacogenomics in Gastrointestinal Disorders Michael Camilleri and Yuri A. Saito 14. Pharmacogenomics in Rheumatoid Arthritis Prabha Ranganathan 15. Cancer Pharmacogenetics Sharon Marsh 16. Pharmacogenomics in the Preclinical Development ofVaccines: Evaluation of Efficacy and Systemic Toxicity in Mouse Using Array Technology Karin J. Regnström 17.Pharmacogenomics in the Evaluation of Efficacy and Adverse Events during Clinical Development of Vaccines Lennart J. Nilsson and Karin J. Regnström