Membrane Transporters in Drug Discovery and Development: Methods and Protocols
Table of Contents:

Table of Contents
Preface
Contributors
1. Membrane Transporters and Drug Development: Relevance to Pharmacogenomics, Nutrigenomics, Epigenetics, and Systems Biology
Qing Yan
2. Bioinformatics for Transporter Pharmacogenomics and Systems Biology: Data Integration and Modeling with UML
Qing Yan
3. Multi Drug Resistance: Phylogenetic Characterization of Superfamilies of Secondary Carriers that Include Drug Exporters
Ming Ren Yen, Jonathan Chen, Jose L. Marquez, Eric I. Sun and Milton H. Saier, Jr.
4. Targeting Drug Transporters - Combining in Silico and In Vitro Approaches to Predict in Vivo
Praveen M. Bahadduri, James E. Polli, Peter W. Swaan and Sean Ekins
5. Methods to Evaluate Transporter Activity in Cancer
Keisuke Mitsuoka, Douglas D. Ross, and Takeo Nakanishi
6. Analysis of Expression of Drug Resistance-Linked ABC Transporters in Cancer Cells by Quantitative RT-PCR
Anna Maria Calcagno and Suresh V. Ambudkar
7. Fluorescence Studies of Drug Binding and Translocation by Membrane Transporters
Frances J. Sharom, Ronghua Liu and Balpreet Vinepal
8. A Model for Transport Studies of the Blood-Brain Barrier
Dennis J. Bobilya
9. Genetic Variants in the Vesicular Monoamine Transporter 1 (VMAT1/SLC18A1) and Neuropsychiatric Disorders
Falk W. Lohoff
10. Equilibrium Binding and Transport by Vesicular Acetylcholine Transporter
Parul Khare, Aubrey R. White, Anuprao Mulakaluri, and Stanley M. Parsons
11. ABC Transporters in Ophthalmic Disease
Corey Westerfeld
12. Imaging of Protein Translocation insitu in Skeletal Muscle of Living Mice
Hans P.M.M Lauritzen
13. Glucose Transporters in Parasitic Protozoa
Scott M. Landfear
14. NMR Studies of Membrane Proteins
Gabriel A. Cook and Stanley J. Opella
15. Site-Directed Mutagenesis in the Study of Membrane Transporters
Audra A. McKinzie, Renae M. Ryan, and Robert J. Vandenberg
16. Xenopus laevis Oocytes
Stefan Bröer
17. Measurement of Intracellular pH
Frederick B. Loiselle and Joseph R. Casey
18. Measurement of Plasma Membrane Calcium-Calmodulin Dependent ATPase (PMCA) Activity
Tamer M. A. Mohamed, Florence M. Baudoin-Stanley, Riham Abou-Leisa, Elizabeth Cartwright, Ludwig Neyses, and Delvac Oceandy
19. Assessment of the Contribution of the Plasma Membrane Calcium ATPase, PMCA, Calcium Transporter to Synapse Function Using Patch Clamp Electrophysiology and Fast Calcium Imaging
Chris J. Roome and Ruth M. Empson