How do you think you would feel if you lost the woman you love dearly to cancer? But after much difficulty, you move on and you open yourself to love one more time. And then, you find out once more that the woman you now love has cancer as well. Isn't that such a cruel twist of fate? If it doesn't get any more ironic, both of you are doctors, and you are able to cure numerous people, but you are unable to cure the one you hold most precious. A Complicated Affair takes you on a winding, emotional journey as a couple tries to find the cure to save not only her life but their love and their future as well.