Taught since 1967, the ME310 course at Stanford University may be the longest-running course in the world. Today ME310 continues to prepare masters' students on how to solve real problems using advanced engineering design and design thinking. Across an academic year, students learn to dance with ambiguity, collaborate in teams, build to think, and make an idea real.Students also learn to work with a wide variety of global innovation leaders - such as Audi, IKEA, GM, Huawei, Lockheed Martin, Merck, Microsoft, Siemens, and more - who provide challenging problems to the student teams. Over the last decade, ME310 has become a global movement, as various universities worldwide have adopted the "ME310 Way" of problem-based learning with global collaboration. This commemorative book describes major themes of ME310 from the perspective of the people involved, and faculty and students share their stories from across the decades to illuminate, reflect upon, and reminisce on this groundbreaking, seminal course.