This work describes the near future technologies and scientific changes that will effect human life in the next 25 years. Artifical intelligence is a major theme of this book as is computing and biotech. The author argues we are in a transitional period in which the major changes of the next quarter century are only barely developed: genome research, human enhancement, computer to computer research, bioinformatics to mention only a few. The author has a qualitative paradigm of what lies ahead and what the AI community can contribute to shaping and creating a world in which both rich, developing and poor nations can benefit. His "posthumanity" posits machine to machine intelligence with potentially positive results for mankind.