Elias G. Carayannis is Full Professor of science, technology, innovation, and entrepreneurship, as well as Co-founder and Co-director of the Global and Entrepreneurial Finance Research Institute (GEFRI) and Director of research on science, technology, innovation and entrepreneurship, European Union Research Center (EURC), at the School of Business of the George Washington University in Washington, D.C. Carayannis' teaching and research activities focus on the areas of strategic government-university-industry R&D partnerships, technology road-mapping, technology transfer and commercialization, international science and technology policy, technological entrepreneurship, and regional economic development.

David F. J. Campbell is Associate Professor (Privatdozent) in Political Science at the University of Vienna; a Faculty Member at the Center for Educational Management and Higher Education Development, Department for Continuing Education Research and Educational Management, at Danube University Krems; a Quality Expert at the University of Applied Arts in Vienna; and a Researcher (Senior Scientist) with the Alpen-Adria-University of Klagenfurt.

Chapter1. Introduction.- Chapter2. Definition of Key Terms: Knowledge, Knowledge Production, Innovation, Democracy, and Governance .- Chapter3. Mode 1, Mode 2 and Mode 3: Triple Helix and Quadruple Helix .- Chapter4. Sustainable Development, Social Ecology and the Quintuple Helix .- Chapter5. Innovation Systems in Conceptual Evolution: Mode 3 Knowledge Production in Quadruple and Quintuple Helix Innovation Systems .- Chapter6. Conclusion: Smart Quintuple Helix Innovation Systems.-