This book is based on naphthoquinones and their biological evaluation for different targets (DNA topoisomerase-I, COX-2, Neuraminidase). Enzyme and cyto-toxicity assay was performed with molecular docking studies. 3, 3¿-(arylmethylene) bis (2-hydroxynaphthalene-1, 4 dione) derivatives were synthesized from lawsone by two methods 1] in presence of LiCl 2] amino acid ester. DNA topoisomerase-I enzyme inhibition studies were conducted with simultaneous and preincubation conditions. Total inhibition compared to Camptothecin as positive control on both the systems of enzyme inhibition systems as well as on Leishmania donovani promastigotes. Diospyrin was isolated in a fairly large quantity from the stem bark of Diospyros montana Roxb.(family: Ebenaceae). Extraction of diospyrin from dried stem bark of Diospyros montana by petroleum ether (60-80) and chloroform in soxhlet apparatus for 2 days. The book describes about the synthetic as well as natural naphthoquinones and their biological evaluation with the help of molecular docking.

I, Dr. Garima Sharma is from Gurugram, Haryana, India and is currently a post graduate student in Department of Conservative Dentistry and Endodontics at Manav Rachna Dental College, Faridabad, India