The objective of this systematic review of the literature was to evaluate and summarize the diagnostic and prognostic potential of Peri Implant Crevicular Fluid(PICF). Included studies were systematically analyzed based on PRISMA (Preferred Reporting Items for Systematic Reviews and Meta Analyses) guidelines. Electronic database search of Pubmed, Medline, Google Scholar and Scopus was performed using MeSH terms and keywords-PICF and Cytokines, IL-1¿, IL-6, IL-4, IL-10, IL-8, IL-17, and TNF-¿, MIP-1¿. Articles published between years 2000-2019 were reviewed and were included based on inclusion and exclusion criteria. Based on this systematic review of literature, the analysis of these components of PICF can reflect the disease status of individual sites and thus, identify potential biomarkers of peri-implant disease status and its application in prognostic significance and response to therapy thereby could prove to be a valuable tool in early diagnosis and management.

Dr. Garima Asthana ist Parodontologin und Implantologin und hat ihr Studium am ITS Dental College, Hospital and Research Centre, Greater Noida, Indien, abgeschlossen. Sie verfügt über eine reiche klinische Erfahrung von 10 Jahren auf dem Gebiet der Zahnmedizin und hat Forschungsarbeit auf dem Gebiet der parodontalen Mikrobiologie und der biochemischen Analyse von PICF geleistet.