Pharmacokinetic and Pharmacodynamic Data Analysis: Concepts and Applications teaches everyday biological data analysis to the undergraduate and graduate levels. Through numerous examples and over 100 tutorials, scientists learn how to use PK/PD seamlessly in a variety of practical areas, from simple plasma kinetics, multi-compartment models, nonlinear kinetics, plasma protein binding, pharmacodynamic models, turnover concepts, receptor binding, functional adaption and rebound, dose-response-time data analysis, inter-species scaling and a lot more. A substantial effort has been invested into the new pharmacokineticsand pharmacodynamics, including many new and updated Case Studies.

General Principles. Introduction. Basic Concepts. Why Model the Data? The Art of Successful Modeling. How to Use This Book. Pharmacokinetic Concepts. Pharmacodynamic Concepts. Modeling Strategies. Elements of Experimental Design. Pattern Recognition. Pharmacokinetic Applications. Pharmacodynamic Applications. References. Symbols and their definitions. Index.

Johan Gabrielsson, Daniel Weiner