Group photograph and outline.- Preface.- List of Participants and Contributors.- A discussion of correlations for narcosis in aquatic species.- Interrelationship between biodegredability, toxicity and structure of chlorophenols.- Structure/ environmental fate relationships.- Bioaccumulation of phenols in zebrafish determined by a dynamic flow through test.- Tissue distribution and elimination of 1,2,3,4-, 1,2,3,5- and 1,2,4,5-tetrachlorobenzene in the rat.- Assessing the administrative utility of the QSAR Information System.- METABOLEXPERT: An expert system for predicting metabolism of substances.- Correlation of biodegradability with atomic charge difference and superdelocalizability.- Prediction of rat oral LD50 from Daphnia magna LC50 and chemical structure.- Factors determining partitioning of hydrophobic organic chemicals in aquatic organisms.- Quantitative structure-activity relationship studies: Acute toxicity of environmental contaminants.- QSAR studies of fish toxicity data of organophosphorus compounds and other classes of reactive organic compounds.- QSAR of acute toxicity of mono-substituted benzene derivatives to Photobacterium phosphoreum.- QSAR of acute toxicity of 1,4-di-substituted benzene derivatives and relationships with the acute toxicity of corresponding mono-substituted benzene derivatives.- Quantitative structure-activity studies of di- and triorganotin compounds.- Relationship between toxicity and bioconcentration for some organic chemicals. I. Examination of the relationship.- Relationship between toxicity and bioconcentration for some organic chemicals. II. Application of the relationship.- Comparison of fish toxicity screening data and QSAR predictions for 48 aniline derivatives.- Partitioning relationships for chlorinated organics between water and particulates in the St. Clair, Detroit and Niagara Rivers.- Quantitative structure- activity relationships (QSAR) and toxicity data in hazard assessment.- Taft sigma and sigma, constants improve log octanol/water partition coefficient based QSAR for fathead minnow toxicity.- The use of luminescent bacteria in the study of structure-toxicity relationships for trichothecenes.- An analysis on published data on fish toxicity of nitrobenzene and aniline derivatives.- Nonempirical modeling of environmental distribution and toxicity of major organic pollutants.- Structure- activity relationships for para-substituted phenols.- Physical-chemical properties of three congeneric series of chlorinated aromatic hydrocarbons.- The relationship between bioaccumulation and lipid content of fish.- Multiparameter correlations between properties of metal ions and their acute toxicity in mice.- Structure-toxicity relationships for industrial chemicals causing type (II) narcosis syndrome.- Influence of life cycle stage on toxicity: The Matacil 1.8D - Chlamydomonas example.- Calmodulin inhibition: A possible predictor of metal-ion toxicity.- Author/Reference Index.- CAS Number Index.- Chemical Formula Index.

Over the past few years, research in the field of quantitative structure-activity relationships (QSAR) in chemistry, biology, pharmacology, toxicology, and environmental sciences has seen strong growth. New journals and books have appeared in each of these fields, however, the combination of QSAR and environmental sciences is still in its infancy. After the success of the Workshop on Quantitative Structure-Activity Relationships (QSAR) in Environmental Toxicology, held at McMaster University, Aug ust 16-18, 1983, with the proceedings publ ished in 1984 [QSA R in Environmental Toxicology, Kaiser, K. L. E. (Ed. ), D. Reidel Pub!. Co. , Dordrecht, 406 p. , ISBN 90-277 -1776-1], it was time to hold another workshop in 1986. Indeed, the response by the scientific community was excellent with over 50 participants from Canada, Germany, Great Britain, Hungary, India, Japan, The Netherlands, United States, and Yugoslavia. Moreover, both breadth and depth of papers given were significantly improved and the workshop discussions were intense and frank. Regrettably, the number of participants, number of papers given and submitted for these proceedings made it impossible to include the workshop discussions of these papers. However, several manuscripts were revised on the basis of these discussions and, therefore, do reflect this very interactive workshop. This volume presents the majority of papers given at the 2nd International Workshop on QSAR in Environmental Toxicology, held at McMaster University, June 9-13, 1986. Many of these papers contain primary, new scientific data, equations and results which will not appear elsewhere.